The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation
نویسندگان
چکیده
منابع مشابه
Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
Toll-like receptors encounter a diversity of degradation products in endosomes. TLR7 and TLR8 have been shown to be activated by RNA degradation products. Here we show that although TLR9 requires single-stranded DNA longer than 20 nucleotides for a robust response, TLR9 activation is augmented by CpG-containing oligodeoxyribonucleotides (sODNs) as short as 2 nucleotides, which, by themselves, d...
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ژورنال
عنوان ژورنال: Immunity
سال: 2008
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2008.01.013